Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TGFB1 All Species: 10.91
Human Site: S274 Identified Species: 30
UniProt: P01137 Number Species: 8
    Phosphosite Substitution
    Charge Score: -0.38
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P01137 NP_000651.3 390 44341 S274 R A Q H L Q S S R H R R A L D
Chimpanzee Pan troglodytes XP_001161571 412 47357 Q296 D N P G Q G G Q R K K R A L D
Rhesus Macaque Macaca mulatta XP_001100842 390 44204 R274 S S L H E R V R S H L K K K K
Dog Lupus familis XP_547918 412 47392 Q296 D N P G Q G G Q R K K R A L D
Cat Felis silvestris
Mouse Mus musculus P04202 390 44291 S274 R A Q H L H S S R H R R A L D
Rat Rattus norvegicus P17246 390 44310 S274 R A Q H L H S S R H R R A L D
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P09531 373 42616 R259 L H S A R R R R D L D T D Y C
Frog Xenopus laevis P16176 382 44182 S266 R I D T V T S S R K K R G V G
Zebra Danio Brachydanio rerio NP_919367 410 46964 R294 L D V L P T S R R R K R A L D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 47.3 85.1 46.1 N.A. 89.7 90 N.A. N.A. 55.3 49.2 46.8 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 61.4 88.9 60.4 N.A. 93.8 93.5 N.A. N.A. 67.4 63.3 62.4 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 33.3 13.3 33.3 N.A. 93.3 93.3 N.A. N.A. 0 33.3 40 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 40 33.3 40 N.A. 93.3 93.3 N.A. N.A. 6.6 53.3 46.6 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 34 0 12 0 0 0 0 0 0 0 0 67 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 12 % C
% Asp: 23 12 12 0 0 0 0 0 12 0 12 0 12 0 67 % D
% Glu: 0 0 0 0 12 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 23 0 23 23 0 0 0 0 0 12 0 12 % G
% His: 0 12 0 45 0 23 0 0 0 45 0 0 0 0 0 % H
% Ile: 0 12 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 34 45 12 12 12 12 % K
% Leu: 23 0 12 12 34 0 0 0 0 12 12 0 0 67 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 23 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 23 0 12 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 34 0 23 12 0 23 0 0 0 0 0 0 0 % Q
% Arg: 45 0 0 0 12 23 12 34 78 12 34 78 0 0 0 % R
% Ser: 12 12 12 0 0 0 56 45 12 0 0 0 0 0 0 % S
% Thr: 0 0 0 12 0 23 0 0 0 0 0 12 0 0 0 % T
% Val: 0 0 12 0 12 0 12 0 0 0 0 0 0 12 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 12 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _